Arizona Sen. John McCain has been part of collective national consciousness for the better part of the last five decades -- ever since his capture and ultimate release five years later (in March 1973) from a Vietnamese prisoner of war camp.
McCain was elected to the seat left behind by the retirement of Sen. Barry Goldwater in 1986.
McCain was largely ignored as a major player in the 2000 presidential race when he announced his candidacy in September 1999. Then-Texas Gov. George W. Bush was considered the all-but-certain nominee.
McCain toppled Bush in the New Hampshire primary, but lost a nasty race in South Carolina that derailed his 2000 presidential bid.
He ran for president in 2008 and started as the front-runner. But the once-in-a-lifetime political talent of Barack Obama ensured that McCain would not see the Oval Office.
In the intervening years, McCain has cemented his role as a hawkish voice on foreign policy, a fierce defender of the military and, yes, someone who occasionally -- and with glee -- throws a wrench into the machinations of his own party.
Following the election of Donald Trump in 2016, McCain has repeatedly blasted the Republican president for his handling of Russia and its efforts to meddle in the election as well as for Trump's firing of former FBI Director James Comey.
McCain was diagnosed with brain cancer in July of 2017.