The car rolled several times, crossing Oldham and landing on the north side of the street.
The two people in the car were conscious when emergency crews arrived, but both were taken to the hospital in serious condition.
One witness told KTAB news they knew it was bad when they saw the car flip across the street.
Damage on the passenger side of the car required firefighters to use the jaws of life to remove the passenger from the vehicle.
The passenger's injuries were significantly worse than the driver's.