The first key is to pressure Chargers quarterback Phillip Rivers. The Cowboys come into this game with 13 sacks, that's good enough for second in the NFL. They must add to that total if they're going to control this San Diego offense that depends entirely on their quarterback.
The second key is DeMarcus Ware must dominate in this game. The Chargers come into this game with three offensive linemen banged up. DeMarcus Ware must take advantage of the situation. He's played Rivers twice in his previous eight seasons, but Ware has never sacked Rivers. He needs to get that first one, maybe the second and the third as well.
The third key to the game is to compensate for the missing Miles Austin. The Cowboys will be without the starting wide receiver on Sunday. That means Dez Bryant is going to get a significant amount of attention, and other receivers will need to step up.
The Cowboys and Chargers kick-off at 3:25 on Sunday afternoon in San Diego.